Effect of ICSI on gene expression and development of mouse preimplantation embryos

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Effect of ICSI on gene expression and development of mouse preimplantation embryos.

BACKGROUND In vitro culture (IVC) and IVF of preimplantation mouse embryos are associated with changes in gene expression. It is however not known whether ICSI has additional effects on the transcriptome of mouse blastocysts. METHODS We compared gene expression and development of mouse blastocysts produced by ICSI and cultured in Whitten's medium (ICSI(WM)) or KSOM medium with amino acids (IC...

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ژورنال

عنوان ژورنال: Human Reproduction

سال: 2012

ISSN: 0268-1161,1460-2350

DOI: 10.1093/humrep/des387